- ProductCode:HOR-235
- Synonyms/ProductAlternateNames:Somatoliberin,Growthhormone-releasingfactor,GRF,Growthhormone-releasinghormone,GHRH,Somatocrinin,Somatorelin,Sermorelin,GHRF,MGC119781,Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Introduction:Growth-hormone-releasinghormone(GHRH),alsoknownasgrowth-hormone-releasingfactor(GRForGHRF)orsomatocrinin,isa44-aminoacidpeptidehormoneproducedinthearcuatenucleusofthehypothalamus.GHRHisreleasedfromneurosecretorynerveterminalsofthesearcuateneurons,andiscarriedbythehypothalamo-hypophysialportalcirculationtotheanteriorpituitaryglandwhereitstimulatesgrowthhormone(GH)secretion.GHRHalsostimulatestheproductionofGH.GHRHisreleasedinapulsatilemanner,stimulatingsimilarpulsatilereleaseofGH.Inaddition,GHRHalsopromotesslow-wavesleepdirectly.Description:GrowthHormoneReleasingHormoneHumanSyntheticisasingle,non-glycosylated,polypeptidechaincontaining29aminoacidsandhavingamolecularmassof3358.9Dalton.Correspondstotheamino-terminalsegmentofthenaturallyoccurringhumangrowthhormone-releasinghormoneconsistingof44aminoacidresidues.TheGHRHispurifiedbyproprietarychromatographictechniques.PhysicalAppearance:SterileFilteredWhitelyophilized(freeze-dried)powder.Formulation:TheGHRHpeptide(1mg/ml)waslyophilizedafterextensivedialysesagainst1.7mgsodiumphosphatebuffer(0.1mgsodiumphosphatemonobasic&1.6mgsodiumphosphatedibasic).Solubility:ItisrecommendedtoreconstitutethelyophilizedGHRHinsterile18MΩ-cmH2Onotlessthan100µg/ml,whichcanthenbefurtherdilutedtootheraqueoussolutions.TheGHRHisalsosolublein1%Aceticacidataconcentrationof>1mg/mltogiveaclear,colorlesssolution.StABIlity:LyophilizedGrowthHormoneReleasingHormonealthoughstableatroomtemperaturefor3weeks,shouldbestoreddesiccatedbelow-18°C.UponreconstitutionGHRFshouldbestoredat4°Cbetween2-7daysandforfutureusebelow-18°C.Forlongtermstorageitisrecommendedtoaddacarrierprotein(0.1%HSAorBSA).Pleasepreventfreeze-thawcycles.Purity:Greaterthan98.0%asdeterminedby:(a)AnalysisbyRP-HPLC.(b)AnalysisbySDS-PAGE.BIOLOGicalActivity:GHRHincreasesplasmagrowthhormoneconcentrationsbydirectlystimulatingtheanteriorpituitaryglandtoreleasenaturalhumangrowthhormone.ForLABORATORYRESEARCHUSEONLY.Theproductmaynotbeusedasdrugs,agriculturalorpesticidalproducts,foodadditivesorhouseholdchemicals.
- StorageConditions:-20°C
- MolecularFormula:C149H246N44O42S
- One-LetterCode:YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2
DeliveryDetails:Allquantitiesaresubjecttoavailability.Pleaseallow7-10daysfordelivery.
