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Minireview Application of the 1,3‐Dipolar Cycloaddition Reaction in Chemical Biology: Approaches Toward Multivalent Carbohydrates and Peptides and Peptide‐Based Polymers Roland J. Pieters Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P. O. Box 80082, 3508 TB Utrecht, The Netherlands, Telephone: +31‐30‐253‐7396/7307, Fax: +31‐30‐253‐6655
Search for more papers by this author Dirk T. S. RijkersMedicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P. O. Box 80082, 3508 TB Utrecht, The Netherlands, Telephone: +31‐30‐253‐7396/7307, Fax: +31‐30‐253‐6655
Search for more papers by this author Rob M. J. LiskampE-mail address: R.M.J.Liskamp@uu.nl
Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P. O. Box 80082, 3508 TB Utrecht, The Netherlands, Telephone: +31‐30‐253‐7396/7307, Fax: +31‐30‐253‐6655
Search for more papers by this author Roland J. PietersMedicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P. O. Box 80082, 3508 TB Utrecht, The Netherlands, Telephone: +31‐30‐253‐7396/7307, Fax: +31‐30‐253‐6655
Search for more papers by this author Dirk T. S. RijkersMedicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P. O. Box 80082, 3508 TB Utrecht, The Netherlands, Telephone: +31‐30‐253‐7396/7307, Fax: +31‐30‐253‐6655
Search for more papers by this author Rob M. J. LiskampE-mail address: R.M.J.Liskamp@uu.nl
Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P. O. Box 80082, 3508 TB Utrecht, The Netherlands, Telephone: +31‐30‐253‐7396/7307, Fax: +31‐30‐253‐6655
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Share onEmailFacebookTwitterLinked InRedditWechatIn this mini review we highlight our recent results and the related literature regarding the application of the Cu(I)‐catalyzed 1,3‐dipolar cycloaddition \"click” reaction. The synthetic applications of the click reaction focus on multivalent carbohydrates and peptides and peptide‐based polymers. Furthermore, a related reaction is described involving the coupling of thio acids and sulfonyl azides leading to the chemoselective formation of amides.
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